Introduction For many people, topical treatments alone are not enough to control moderate to severe acne. When breakouts are persistent, painful, widespread, or cause scarring, dermatologists often turn to oral prescription medications. These systemic treatments work from the inside out to reduce inflammation, regulate hormones, control bacteria, and shrink oil glands.The most commonly used oral medications include antibiotics, birth control pills, and isotretinoin (Accutane). Each targets acne differently and is recommended for specific situations.This comprehensive guide explains how each medication works, who needs it, how long treatment lasts, possible side effects, and when to consult a dermatologist. Why Oral Medications…