Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) and medications commonly prescribed to manage high blood pressure and heart failure, such as angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARBs), are often used together to treat a variety of conditions. While these drugs are effective individually, their combined use can sometimes lead to dangerous interactions, creating a phenomenon known as the “Triple Whammy Effect.” This term refers to the adverse effects that arise when NSAIDs, ACE inhibitors, and ARBs are taken simultaneously, potentially causing serious harm to kidney function, blood pressure regulation, and overall cardiovascular health. Understanding this interaction is crucial…