Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to manage pain and inflammation, making them one of the most commonly prescribed classes of medications globally. These drugs are effective in treating conditions such as arthritis, muscle pain, and other inflammatory disorders. However, one of the key considerations when prescribing NSAIDs is their potential for drug interactions that can alter the absorption and effectiveness of other medications. Among the many substances that interact with NSAIDs, antacids and cholestyramine are notable. Both of these agents have the potential to interfere with the absorption of NSAIDs, which can lead to reduced therapeutic efficacy…