Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to manage pain, inflammation, and fever. However, when combined with antihypertensive medications, NSAIDs can compromise blood pressure control and increase the risk of cardiovascular events. This interaction is especially concerning for patients with chronic conditions such as hypertension, heart failure, or chronic kidney disease, where effective blood pressure management is critical to preventing complications. Understanding how NSAIDs interfere with antihypertensive therapy, identifying at-risk populations, and applying practical management strategies can help healthcare providers minimize these risks and ensure safer, more effective treatment regimens. Interaction Mechanisms The interaction between NSAIDs and antihypertensive agents…