Introduction: Neonatal sepsis is a severe medical condition occurring in newborns, characterized by systemic infection and inflammation. It remains a leading cause of neonatal morbidity and mortality worldwide. Moreover, Effective prevention and then timely treatment are important to improve outcomes for affected neonates.   Preventing Neonatal Sepsis Prevention strategies for neonatal sepsis focus on reducing risk factors and then  implementing proactive measures both during pregnancy and after delivery.   Maternal Screening and Prophylaxis Group B Streptococcus (GBS) Screening: Pregnant women are routinely screened for GBS during the third trimester (35-37 weeks). Moreover, Intrapartum antibiotic prophylaxis (IAP) is administered to GBS-positive…