Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used medications for the management of pain, inflammation, and fever. Meanwhile, beta-blockers are widely prescribed as first-line agents for the treatment of hypertension, heart failure, and other cardiovascular conditions. While each drug class serves vital therapeutic roles, their concurrent use can lead to significant drug interactions, particularly affecting blood pressure control. One of the most clinically relevant concerns is the potential reduction in antihypertensive efficacy of beta-blockers when used in conjunction with NSAIDs. This interaction is especially important for patients with comorbid conditions requiring both pain management and blood pressure control. Understanding the…