Introduction Fatigue is one of the most common and debilitating symptoms of systemic lupus erythematosus (SLE), commonly known as lupus. For many individuals living with this autoimmune disease, fatigue is more than just feeling tired—it is a deep, persistent exhaustion that interferes with daily life, work, relationships, and overall well-being. While lupus fatigue often goes unseen by others, its impact is profound. It can occur even when the disease is inactive, and it may not always correlate with physical activity or rest. Understanding the causes of fatigue in lupus and learning effective coping strategies are critical for improving quality of…