Introduction: DNA damage is a ubiquitous threat to genomic integrity, posing a constant challenge to cells’ survival and proliferation. In cancer, dysregulation of DNA damage response (DDR) pathways can lead to genomic instability, a hallmark of tumorigenesis. Moreover, The complex mechanisms of DNA damage, repair, and mutagenesis in cancer development are essential for identifying therapeutic targets and then devising effective treatment strategies. This blog explains the molecular intricacies of DNA damage and repair in cancer, highlighting vulnerabilities that can be exploited for therapeutic intervention. DNA Damage and Repair Mechanisms: DNA damage can arise from various sources, including endogenous metabolic…
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Introduction: Solid organ transplant recipients face unique challenges when diagnosed with cancer due to the interplay between immunosuppressive therapy and cancer immunotherapy. While cancer immunotherapy has revolutionized cancer treatment in the general population, its safety and efficacy in solid organ transplant recipients remain uncertain. In this blog, we explore the complex landscape of cancer immunotherapy in transplant recipients, examining safety concerns, potential efficacy, and the challenges of managing cancer in this vulnerable patient population. Safety Considerations: Solid organ transplant recipients are maintained on long-term immunosuppressive therapy to prevent allograft rejection, which poses a significant barrier to the safety of…
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Introduction: In recent years, the role of epigenetic modifications, particularly DNA methylation, in cancer development, progression, and treatment resistance has garnered significant attention. Moreover, This blog aims to discuss the intricate mechanisms of DNA methylation, its implications in cancer biology, and then the therapeutic potential it holds in the realm of cancer treatment. Understanding DNA Methylation: DNA methylation is a fundamental epigenetic modification that plays an important role in gene regulation and cellular function. This process involves the addition of a methyl group to the cytosine residue of DNA, typically occurring at CpG dinucleotides. DNA methylation patterns are dynamic…