Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are widely used medications, each effective for treating a range of inflammatory conditions, pain, and autoimmune diseases. However, their combined use presents significant gastrointestinal (GI) risks that can lead to severe complications such as ulcers, bleeding, and perforations. The use of both NSAIDs and corticosteroids concurrently amplifies these risks, creating a dangerous combination that requires careful management. NSAIDs, including commonly used drugs such as ibuprofen, aspirin, and naproxen, work by inhibiting cyclooxygenase (COX) enzymes, which reduce the production of prostaglandins. While this action helps control inflammation and pain, it also disrupts the protective…