Introduction As the COVID-19 virus continues to evolve, so does our understanding of how best to protect against it. With newer variants like JN.1 and KP.3 circulating in 2025, vaccine guidance has been updated to match the changing landscape of viral transmission and immunity. This article explores the latest vaccine recommendations, including who should get vaccinated, when boosters are needed, and why it remains crucial — even as the acute crisis phase of the pandemic has passed. Why Updated Vaccine Guidance Is Needed The SARS-CoV-2 virus constantly mutates. Each mutation can affect: Because of this, vaccines must be updated periodically…