Introduction Over-the-counter (OTC) medications play a crucial role in managing common health issues, from pain relief and cold symptoms to allergy control and digestive health. For millions of Americans without health insurance, OTC drugs are often the first—and sometimes only—line of defense against illness. However, rising costs and limited access to affordable options have created a significant crisis. Many uninsured individuals and families face tough decisions between buying essential medications and covering other basic needs. This article explores the OTC affordability challenges faced by uninsured Americans, the impact on health outcomes, existing assistance programs, and potential policy solutions to improve…