Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications worldwide, widely prescribed for their analgesic, antipyretic, and anti-inflammatory effects. Diuretics, on the other hand, are essential agents in managing hypertension, heart failure, and edema. While both drug classes are effective in their respective roles, their concurrent use can lead to significant renal complications, especially in vulnerable populations. When used together, NSAIDs and diuretics can produce deleterious effects on renal perfusion and electrolyte balance, sometimes culminating in acute kidney injury (AKI). This article explores the mechanisms behind their interaction, the clinical consequences observed in practice, and strategies to…