Introduction: DNA damage is a ubiquitous threat to genomic integrity, posing a constant challenge to cells’ survival and proliferation. In cancer, dysregulation of DNA damage response (DDR) pathways can lead to genomic instability, a hallmark of tumorigenesis. Moreover, The complex mechanisms of DNA damage, repair, and mutagenesis in cancer development are essential for identifying therapeutic targets and then devising effective treatment strategies. This blog explains the molecular intricacies of DNA damage and repair in cancer, highlighting vulnerabilities that can be exploited for therapeutic intervention. DNA Damage and Repair Mechanisms: DNA damage can arise from various sources, including endogenous metabolic…
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Introduction: When the genes in your body are affected by a mutation—a negative change to a gene also known as a pathogenic variant—or when you have an improper amount of genetic material, genetic illnesses can develop. DNA (deoxyribonucleic acid), which makes up genes, contains instructions for how cells should function as well as the traits that distinguish people from one another. Each biological parent provides you with half of your DNA, and you may inherit a gene mutation from one or both of your parents. Genes can occasionally change as a result of problems with the DNA (mutations). Your chance…