Introduction In modern medicine, it’s not uncommon for patients to be prescribed medications from different therapeutic classes to manage multiple conditions simultaneously. Two such commonly prescribed classes are Selective Serotonin Reuptake Inhibitors (SSRIs) for depression and anxiety, and triptans for migraine headaches. Both are effective in their respective domains. However, when used in combination, they can pose a serious risk—serotonin syndrome—a potentially life-threatening condition resulting from excessive serotonergic activity in the central nervous system. While serotonin syndrome is relatively rare, its potential severity demands clinical attention. Understanding the mechanisms behind this interaction, identifying patients at risk, and knowing how to…