Introduction For decades, phenylephrine has been a common ingredient in over-the-counter (OTC) cold and allergy medications marketed as effective nasal decongestants. Found in popular brands like Sudafed PE, DayQuil, and Tylenol Sinus, oral phenylephrine was widely assumed to relieve nasal congestion by shrinking blood vessels in the nasal passages. However, in a dramatic turn of events, experts from the U.S. Food and Drug Administration (FDA) have declared that oral phenylephrine is ineffective when taken at the recommended dose. This revelation has sparked national attention, consumer confusion, and calls for reform in how cold medications are regulated. The FDA’s Nonprescription Drugs…