Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective serotonin reuptake inhibitors (SSRIs) are among the most commonly prescribed medications worldwide. NSAIDs like ibuprofen, naproxen, and diclofenac are extensively used for pain relief, inflammation, and fever, while SSRIs such as fluoxetine, sertraline, and citalopram are widely prescribed for depression, anxiety, and other mood disorders. Despite their therapeutic benefits, both drug classes carry the potential for gastrointestinal (GI) side effects. When used together, the risk of GI complications increases significantly. This drug interaction is often overlooked in clinical practice but can result in serious outcomes such as gastrointestinal bleeding and ulceration. Understanding the…