Introduction Lithium is a cornerstone mood stabilizer widely prescribed for the treatment of bipolar disorder and other mood-related conditions. It has proven efficacy in reducing the frequency and severity of manic and depressive episodes, and in some cases, it may even reduce suicide risk. However, lithium has a narrow therapeutic index, meaning the margin between therapeutic and toxic levels is small, requiring careful dose management and frequent monitoring. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for managing pain, inflammation, and fever. Given the prevalence of both bipolar disorder and chronic pain conditions, it is not uncommon for patients to be…