Introduction Sore throat, fatigue, and swollen tonsils are common symptoms of both strep throat and mononucleosis (mono)—two illnesses that often affect teenagers and young adults. Despite their similarities, these conditions are caused by different pathogens, require different treatments, and have distinct long-term implications. Misdiagnosing one for the other can delay proper care or even lead to complications. This article breaks down the key differences between strep throat and mono, covering their causes, symptoms, diagnostic tools, treatment approaches, and recovery timelines. Causes: Bacteria vs. Virus The cause matters significantly because strep throat requires antibiotics, while mono does not—it’s viral and must…