Introduction For decades, oral phenylephrine has been a staple in over-the-counter (OTC) cold and allergy medications marketed as nasal decongestants. However, recent evaluations by the U.S. Food and Drug Administration (FDA) and independent researchers have concluded that oral phenylephrine is largely ineffective at relieving nasal congestion. As a result, consumers, clinicians, and pharmaceutical companies are urgently exploring alternatives. This article delves into the emerging innovations and options that promise more effective and safer relief for nasal congestion in the post-phenylephrine era. Current Effective Alternatives to Oral Phenylephrine With the diminishing credibility of oral phenylephrine, many are turning to well-established alternatives…