Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) and probenecid are two classes of drugs often used in the treatment of various medical conditions. NSAIDs are commonly prescribed for pain, inflammation, and fever, while probenecid is used to treat gout by enhancing the renal excretion of uric acid. Both medications have independent roles in managing patients’ health, but when taken together, they can lead to altered drug levels, causing a range of clinical consequences. The interaction between NSAIDs and probenecid arises due to their effects on renal drug excretion. This article explores how these two classes of drugs interact at the pharmacokinetic level,…