Introduction Access to over-the-counter (OTC) medications is often taken for granted in urban and suburban areas, where pharmacies and retail stores are readily available. However, in many rural parts of America, residents face significant challenges obtaining these essential medications. Known as “medicine deserts,” these areas experience limited access to pharmacies, resulting in barriers that negatively affect health outcomes. This article explores the scope of rural pharmacy closures, transportation obstacles, health impacts, innovative solutions, and policy efforts aimed at improving OTC medication access in rural America. Scope of Rural Pharmacy Closures and Access Issues Over the past decade, rural communities across…