Introduction In an evolving healthcare landscape that emphasizes accessibility, cost-effectiveness, and patient empowerment, Rx-to-OTC drug switches have emerged as a key strategy for expanding self-care options. These switches occur when medications once available only by prescription gain approval for over-the-counter (OTC) sale. The shift reflects growing trust in consumer health literacy and demand for greater convenience in managing common health conditions. From allergy relief to heartburn treatment, many once-prescription drugs have made successful transitions to the pharmacy shelf. However, this transformation involves rigorous evaluation by the U.S. Food and Drug Administration (FDA), as well as ongoing concerns about safety, affordability,…