Introduction Dandruff is a common scalp condition characterized by flaking, itching, and irritation. While over-the-counter shampoos and natural remedies are effective for many people, some cases are stubborn or severe. Persistent dandruff may be a result of seborrheic dermatitis, psoriasis, or fungal overgrowth, requiring prescription-strength treatments. This article explores prescription options for managing stubborn dandruff, including topical and oral medications, how they work, and guidelines for safe use. When Is Prescription Treatment Needed? Topical Prescription Treatments 1. Ketoconazole 2% or 4% 2. Ciclopirox 3. Topical Corticosteroids 4. Topical Calcineurin Inhibitors Oral Prescription Treatments (For Severe or Refractory Cases) 1. Oral…