Introduction In recent years, sublingual medications—those designed to dissolve under the tongue—have gained significant attention in the over-the-counter (OTC) drug market. Unlike traditional oral medications that require swallowing and digestion, sublingual drugs leverage the thin mucous membrane under the tongue to deliver active ingredients directly into the bloodstream. This route allows for faster onset of action and improved bioavailability, making sublingual formulations attractive for consumers seeking rapid relief from common ailments. This article explores the mechanisms behind sublingual absorption, current OTC sublingual products, their advantages and limitations, manufacturing challenges, and consumer trends shaping this innovative delivery system. Sublingual Absorption Mechanisms…