Introduction Lyme disease, caused by the Borrelia burgdorferi bacterium and spread through tick bites, is usually treatable with antibiotics. However, for some individuals, symptoms persist even after completing treatment. This condition is known as Post-Treatment Lyme Disease Syndrome (PTLDS). PTLDS can be confusing and frustrating, both for patients and healthcare providers. Though the initial infection has been treated, lingering symptoms may impact daily life. This article explores what PTLDS is, its possible causes, symptoms, diagnosis, and current management strategies. What Is Post-Treatment Lyme Disease Syndrome (PTLDS)? PTLDS refers to a set of long-lasting symptoms that continue for 6 months or…