Introduction: The tumor microenvironment (TME) plays a major role in tumor initiation, progression, and response to therapy. Gastrointestinal (GI) and respiratory cancers represent a diverse array of malignancies with unique TME characteristics that evolve dynamically during disease progression and in response to treatment. The dynamic interplay between tumor cells and the TME is essential for unraveling the complexities of cancer biology and developing targeted therapeutic strategies. This blog delves into the dynamic changes occurring within the TME of GI and respiratory cancers, shedding light on the mechanisms driving tumor ecosystem remodeling during disease progression and treatment.   The Tumor Ecosystem…