Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed medications for managing pain and inflammation. They are widely used to treat conditions such as arthritis, muscle injuries, and other inflammatory disorders. On the other hand, valproic acid is an anticonvulsant and mood stabilizer, used to treat conditions like epilepsy, bipolar disorder, and in some cases, migraine prevention. While both drugs are effective in their respective uses, their concurrent administration can result in clinically significant interactions. One of the most important interactions between NSAIDs and valproic acid is related to protein binding. Valproic acid and many NSAIDs are highly…