Introduction Weight management is often thought of as a simple equation of calories in versus calories out. While energy balance is certainly important, the body’s internal hormonal system plays a major role in regulating appetite, metabolism, and fat storage. Among these hormones, leptin and ghrelin are two of the most critical players. Often referred to as the “hunger hormones,” they act as messengers between the gut, fat stores, and the brain to help control food intake and body weight. Understanding how leptin and ghrelin function—and how imbalances can affect weight—can provide valuable insight into why weight loss is so challenging…